flowrate

A size-structured matrix population model to estimate rates of cell division, carbon fixation and carbon loss in phytoplankton measured by flow cytometry.

The rates of cell growth, division, and carbon loss of microbial populations in their natural habitat are key parameters for understanding how organisms interact with their environment and how they contribute to the carbon cycle. However, the invasive nature of current analytical methods has hindered efforts to reliably quantify these parameters. Here, we present a flexible Bayesian formulation of size-structured matrix population model for testing a set of underlying assumptions describing microbial population dynamics. We incorporate the model into a Bayesian framework that not only takes into account prior scientific knowledge but also generates biologically interpretable results.

Description of the model is available here: https://doi.org/10.1371/journal.pcbi.1009733

Code is available here: https://github.com/seaflow-uw/mpm-workflow